Izindaba

Umlando nokuvela kwe-anesthesia ye-intrevenous

Ukuphathwa kwe-Intravenous kwezidakamizwa izinsuku zibuyele emuva ngekhulu leshumi nesikhombisa lapho uChristopher ebhula ejola inja esebenzisa inja esebenzisa i-goose quill kanye ne-stupefied '. Ngawo-1930s hexobarbital nePentothal bangeniswa ekusebenzeni emtholampilo.

Kwakungo-1960s ekhemisi amamodeli kanye nezilinganiso ze-IV infyway zakhiwa futhi ngama-1980s, izinhlelo ezilawulwa yi-IV ezilawulwa yi-IV zethulwe. Ngo-1996 uhlelo lokuqala olulawulwa ukumiswa okulawulwa (i-'Piprufusor ') yethulwa.

Isichasiso

A Ithango elilawulwa elilawulwaIngabe ukumnika okulawulwa ngendlela efanayo nokuzama ukufeza ukufezekiswa komsebenzisi okuchazwe kabusha kwezidakamizwa egumbini lomzimba lenzalo noma izicubu zentshisekelo. Lo mqondo uphakanyiswe okokuqala nguKruger Thiemer ngo-1968.

Pharmacokinetics

Ivolumu yokusatshalaliswa.

Le yivolumu ebonakalayo lapho umuthi usakazwa khona. Kubalwa ngefomula: VD = umthamo / ukugxila kwezidakamizwa. Inani layo lincike ekutheni libalwa ngesikhathi ze-zero - ngemuva kwe-bolus (VC) noma esimweni esiqinile ngemuva kokufakwa (vss).

Imvume.

Ukuvulwa kumelela ivolumu ye-plasma (VP) lapho umuthi usuqedwa khona ngesikhathi seyunithi ngayinye ukuze akwazi ukuqeda ukuqedwa kwawo emzimbeni. Imvume = ukuqeda x vp.

Njengoba imvume yandisa impilo ye-Half-life, futhi njengoba ivolumu yokusatshalaliswa inyuka kanjalo nengxenye yempilo. Ukuvulwa kungasetshenziswa futhi ukuchaza ukuthi umuthi uqhubeka kanjani phakathi kwezindawo. Lesi sidakamizwa ekuqaleni sasatshalaliswa egumbini eliphakathi ngaphambi kokusatshalaliswa ezingxenyeni ezihlangene. Uma ivolumu yokuqala yokusabalalisa (i-VC) kanye nokuhlushwa okufiselekayo komphumela wezokwelapha (CP) kuyaziwa, kungenzeka ukubala umthamo wokulayisha ukufeza lokho okuhlushwa:

Ukulayisha umthamo = cp x vc

Ingasetshenziswa futhi ukubala umthamo we-bolus odingekayo ukuze kukhulise ngokushesha ukugxila ngesikhathi sokumnika okuqhubekayo: I-Bolus Dose = (CNEWS - CATCUAL) X VC. Izinga lokufakwa ukuze ligcine isimo esiqinile = CP X imvume.

Ama-regimens alula angenayo awafinyeleli ukugxila kwe-plasma eqinile kuze kube okungenani iziphindaphindo ezinhlanu zokuqedwa kwempilo. Ukuhlushwa okufiselekayo kungatholakala ngokushesha uma umthamo we-bolus ulandelwa yizinga lokungena.