Izindaba

I-Pharmacokineticamamodeli azama ukuchaza ubudlelwano phakathi komthamo kanye nokuhlushwa kwe-plasma maqondana nesikhathi. Imodeli ye-pharmacokinetic iyimodeli yezibalo engasetshenziswa ukubikezela iphrofayili yokuhlushwa kwegazi komuthi ngemuva komthamo we-bolus noma ngemuva kokufakwa isikhathi esihlukahlukene. Lawa mamodeli ngokuvamile atholakala ngendlela yokulinganisa ukuhlushwa kwe-plasma yemithambo yegazi noma yemithambo yegazi ngemuva kokufakwa kwe-bolus noma ukufakwa eqenjini lamavolontiya, kusetshenziswa izindlela ezijwayelekile zezibalo kanye namamodeli esofthiwe yekhompyutha.

Amamodeli ezibalo akhiqiza amanye amapharamitha e-pharmacokinetic njengomthamo wokusatshalaliswa kanye nokususwa. Lokhu kungasetshenziswa ukubala umthamo wokulayisha kanye nesilinganiso sokufakwa okudingekayo ukuze kulondolozwe ukuhlushwa kwe-plasma okuzinzile ekulinganeni.

Njengoba kuye kwaqashelwa ukuthi i-pharmacokinetics yezidakamizwa eziningi zokubulala izinzwa ivumelana kangcono nemodeli yezingxenye ezintathu, kuye kwanyatheliswa ama-algorithm amaningi okuhlosisa amazinga egazi kanye nendawo yomphumela futhi kuye kwathuthukiswa izinhlelo eziningana ezenzakalelayo.