IkhemisiAmamodeli azama ukuchaza ubudlelwano phakathi kokuthambekela kwethamo ne-plasma maqondana nesikhathi. Imodeli ye-pharmacokinetic iyimodeli yezibalo engasetjenziswa ukubikezela iphrofayili yokuhlushwa kwegazi ngesidakamizwa ngemuva komthamo we-bolus noma ngemuva kokufakwa kwezikhathi ezahlukahlukene. Lawa mamodeli athathwe ngokujwayelekile alinganiswa ngefomu lokulinganisa le-plasma elingafanele noma le-venous ngemuva kwe-bolus noma ukumnika eqenjini lamavolontiya, esebenzisa izindlela ezijwayelekile zezibalo namamodeli wesoftware yekhompyutha.
Amamodeli wezibalo akhiqiza amanye amapharamitha we-pharmacokinetic anjengevolumu yokusatshalaliswa kanye nokuvunyelwa. Lokhu kungasetshenziselwa ukubala umthamo wokulayisha kanye nesilinganiso sokumnika okudingekayo ukuze ulondoloze ukugxila kwe-plasma eqinile e-Equilibrium.
Njengoba iye yaqashelwa ukuthi ama-Pharmacokinetics ama-ejenti amaningi azwakala avumelanisa kangcono nemodeli emithathu yamakhemikhali, ama-algorithm amaningi okubhekisa egazini kanye nokuhlangana kwesayithi okushicilelwe kushicilelwe futhi kwakhiwa izinhlelo ezimbalwa ezenzakalelayo.
Isikhathi sePosi: Nov-05-2024