I-Pharmacokineticamamodeli azama ukuchaza ubudlelwano phakathi kwethamo nokugxilwa kwe-plasma ngokuphathelene nesikhathi. Imodeli ye-pharmacokinetic imodeli yezibalo engasetshenziswa ukubikezela iphrofayili yokugxiliswa kwegazi lomuthi ngemva komthamo we-bolus noma ngemva kokumnika isikhathi esihlukile. Lawa mamodeli ngokuvamile asuselwa kufomu lokulinganisa ukugxila kwe-arterial noma i-venous plasma ngemva kwe-bolus noma ukumnika eqenjini lamavolontiya, kusetshenziswa izindlela zezibalo ezimisiwe namamodeli esofthiwe yekhompyutha.
Amamodeli ezibalo akhiqiza imingcele ethile ye-pharmacokinetic efana nevolumu yokusabalalisa kanye nemvume. Lezi zingasetshenziswa ukubala umthamo wokulayisha kanye nezinga lokumnika elidingekayo ukuze kugcinwe ukugxiliswa kwe-plasma yesimo sokuzinza ngesikhathi sokulingana.
Njengoba kuye kwaqashelwa ukuthi i-pharmacokinetics yama-ejenti amaningi okubulala izinzwa ivumelana kangcono nemodeli yekhompathi ezintathu, izindlela eziningi zokuxazulula izinkinga zokukhomba igazi kanye nokugxiliswa kwesizinda semiphumela ziye zashicilelwa futhi kwasungulwa nezinhlelo ezimbalwa ezizenzakalelayo.
Isikhathi sokuthumela: Nov-05-2024