Izindaba

Ngo-1968, uKruger-Theimer wabonisa indlela amamodeli e-pharmacokinetic angasetshenziswa ngayo ukuklama izindlela zokulinganisa umthamo eziphumelelayo. Lolu hlelo lwe-Bolus, Elimination, Transfer (BET) luqukethe:

umthamo we-bolus obalwa ukugcwalisa ingxenye ephakathi (yegazi),

ukumnika okulinganiselwe okulingana nesilinganiso sokukhipha,

ukumnika okusiza ekudluliseleni ezicutshini ezingaphandle: [izinga lokunciphisa ngokubonakalayo]

Umkhuba wendabuko wawuhilela ukubala uhlelo lokufaka i-propofol ngendlela kaRoberts. Umthamo wokulayisha ongu-1.5 mg/kg ulandelwa ukuphakelwa okungu-10 mg/kg/ihora okuncishiswa kube amazinga angu-8 no-6 mg/kg/ihora ngezikhathi zemizuzu eyishumi.

Ukuqondisa indawo okunemiphumela

Imiphumela eyinhloko yeumuthi wokubulala izinzwaAma-ejenti e-intravenous ayimiphumela yokudambisa kanye ne-hypnotic futhi indawo lapho umuthi uveza khona le miphumela, ebizwa ngokuthi indawo yomphumela ubuchopho. Ngeshwa akunakwenzeka emtholampilo ukukala ukuhlushwa kobuchopho [indawo yomphumela]. Ngisho noma singalinganisa ukuhlushwa kobuchopho ngqo, kuzodingeka ukwazi ukuhlushwa kwesifunda okuqondile noma ngisho nokuhlushwa kwama-receptor lapho umuthi uveza khona umphumela wawo.

Ukufinyelela ukuhlushwa kwe-propofol okuqhubekayo

Umdwebo ongezansi ubonisa izinga lokufakwa elidingekayo ngesilinganiso esinciphayo kakhulu ngemva komthamo we-bolus ukuze kulondolozwe izinga elizinzile le-propofol egazini. Uphinde ubonise ukulibala phakathi kokulibaziseka kwegazi nendawo yomphumela.