Ngo-1968, u-Kruger-Theimer wabonisa ukuthi amamodeli e-pharmacokinetic angasetshenziswa kanjani ukuklama imithi yomthamo ephumelelayo. Lolu hlobo lwe-Bolus, Elimination, Transfer (BET) luqukethe:
umthamo we-bolus obalwe ukugcwalisa indawo emaphakathi (igazi),
ukumnika okujwayelekile okulingana nezinga lokuqeda,
ukumnika okunxephezela ukudluliselwa kumathishu aseduze: [izinga elincipha kakhulu]
Umkhuba wendabuko wawuhilela ukubala uhlobo lwemithi ye-propofol ngendlela ye-Roberts. Umthamo wokulayisha we-1.5 mg/kg ulandelwa ukumnika kwe-10 mg/kg/ihora okuncishiswa kumazinga we-8 kanye no-6 mg/kg/hr ngezikhathi zemizuzu eyishumi.
Ukukhomba isayithi lomthelela
Imiphumela eyinhloko yei-anesthetici-intravenous agents ziyimiphumela yokulalisa kanye ne-hypnotic kanye nesayithi lapho umuthi usebenzisa le miphumela, ebizwa ngokuthi indawo yomphumela ubuchopho. Ngeshwa akwenzeki emisebenzini yomtholampilo ukukala ukugxila kobuchopho [indawo yomphumela]. Ngisho noma besingakwazi ukukala ukugxiliswa kobuchopho okuqondile, kungadingeka ukwazi ukugxilisa okuqondile kwesifunda noma ukugxiliswa kwesamukeli lapho umuthi wenza khona umphumela wawo.
Ukuthola ukuhlushwa kwe-propofol njalo
Umdwebo ongezansi ubonisa izinga lokumnika elidingekayo ngezinga elehla ngokushesha ngemva komthamo we-bolus ukuze kugcinwe ukugxiliswa kwegazi okuzinzile kwe-propofol. Iphinde ibonise ukugoba phakathi kwegazi kanye nokugxila kwesayithi.
Isikhathi sokuthumela: Nov-05-2024