Amamodeli e-pharmacokinetic alawulwa yikhompyutha
Ukusebenzisa ai-pharmacokineticimodeli, ikhompuyutha ibala ngokuqhubekayo umthamo wezidakamizwa olindelekile wesiguli futhi isebenzise uhlobo lwe-BET, ilungisa amazinga okufakwa kwephampu, ngokuvamile ngezikhawu zemizuzwana eyi-10. Amamodeli athathwe ezifundweni ze-pharmacokinetic zabantu ezenziwa ngaphambilini. Ngokuhlela ukugxilwa kwethagethi oyifunayo, iobulala izinzwaisebenzisa idivayisi ngendlela efana ne-vaporizer. Kunomehluko phakathi kokugxilisa okubikezelwe kanye nokwangempela, kodwa lokhu akunawo umphumela omkhulu, inqobo nje uma ukugxila kwangempela kungaphakathi kwewindi lokwelapha lomuthi.
I-pharmacokinetics yesiguli kanye ne-pharmacodynamics iyahlukahluka ngokweminyaka, ukuphuma kwenhliziyo, izifo ezihlala isikhathi eside, ukuphathwa kwezidakamizwa kanyekanye, izinga lokushisa lomzimba nesisindo sesiguli. Lezi zici zidlala indima ebalulekile ekukhetheni ukugxila okuhlosiwe.
U-Vaughan Tucker usungule uhlelo lokuqala olusiza ikhompyutha ye-IV [CATIA]. Eyokuqala commercialukumnika okulawulwa okuhlosiweidivayisi kwakuyi-Diprufusor eyethulwe i-Astra Zeneca, enikezelwe ekuphathweni kwe-propofol phambi kwesirinji ye-propofol egcwele ngaphambili enomucu kazibuthe ekuvulekeni kwayo. Amasistimu amaningi amasha ayatholakala ukuze asetshenziswe manje. Idatha yesiguli efana nesisindo, ubudala nobude kuhlelwa kupompo kanye nesofthiwe yepompo, kusetshenziswa ukulingisa kwe-pharmacokinetic, ngaphandle kokuphatha nokugcina amazinga okumnika afanelekile, kubonisa ukugxila okubaliwe kanye nesikhathi esilindelekile sokululama.
Isikhathi sokuthumela: Dec-10-2024