Amamodeli e-pharmacokinetic alawulwa yikhompyutha
Ukusebenzisa i-i-pharmacokineticimodeli, ikhompyutha ibala njalo ukuhlushwa kwesiguli okulindelekile kwemithi bese ihlinzeka ngohlelo lwe-BET, ilungisa amazinga okufakwa kwepompo, ngokuvamile ngezikhawu zemizuzwana eyi-10. Amamodeli atholakala ezifundweni ze-pharmacokinetic zabantu ezenziwe ngaphambilini. Ngokuhlela ukuhlushwa okuhlosiwe okufunwayo,udokotela wezinzwaisebenzisa idivayisi ngendlela efana ne-vaporizer. Kukhona umehluko phakathi kokuhlushwa okubikezelwe kanye nokuhlushwa kwangempela, kodwa lokhu akubalulekile kakhulu, uma nje ukuhlushwa kwangempela kusefasiteleni lokwelapha lomuthi.
I-pharmacokinetics yesiguli kanye ne-pharmacodynamics ziyahlukahluka ngokweminyaka, umphumela wenhliziyo, isifo esihambisanayo, ukuphathwa kwemithi ngasikhathi sinye, izinga lokushisa lomzimba kanye nesisindo sesiguli. Lezi zici zidlala indima ebalulekile ekukhetheni amazinga okuhlosiwe.
UVaughan Tucker wasungula uhlelo lokuqala lokubulala izinzwa olusebenzisa ikhompyutha olusebenzisa i-total IV [CATIA]. Isikhangiso sokuqalaukufakwa okulawulwa okuqondiweIdivayisi yayiyi-Diprufusor eyethulwa yi-Astra Zeneca, enikezelwe ekuphathweni kwe-propofol phambi kwesirinji ye-propofol egcwaliswe ngaphambilini ene-magnetic strip eflangeni layo. Izinhlelo eziningi ezintsha ziyatholakala ukuze zisetshenziswe manje. Imininingwane yesiguli efana nesisindo, ubudala nokuphakama ihlelwe ephampini kanye nesofthiwe yephampu, ngokusebenzisa ukulingisa kwe-pharmacokinetic, ngaphandle kokuphatha nokugcina amazinga okufakwa afanele, kubonisa amazinga abaliwe kanye nesikhathi esilindelekile sokululama.
Isikhathi sokuthunyelwe: Disemba 10-2024